Close
  Indian J Med Microbiol
 

Figure 1: A graphical representation of antiviral mechanisms of CQ and HCQ. 1. The drugs interfere with glycosylation of ACE-2 and decreases its binding efficiency of ACE2 on host cells with spike S protein on coronavirus surface. 2. Increases pH of lysosomes, preventing fusion of virus with host cell and thus, virus replication is prevented. 3. Inhibition of autolysosome formation and thus, inhibition of autophagy. 4. Inhibition of endosomal acidification. 5. Inhibition of MAP-Kinase, thus inhibiting molecular crosstalk in viruses, and inhibiting virus particle assembly and budding. @Corresponding author, Sahu M, Shankar SH, et al.

Figure 1: A graphical representation of antiviral mechanisms of CQ and HCQ. 1. The drugs interfere with glycosylation of ACE-2 and decreases its binding efficiency of ACE2 on host cells with spike S protein on coronavirus surface. 2. Increases pH of lysosomes, preventing fusion of virus with host cell and thus, virus replication is prevented. 3. Inhibition of autolysosome formation and thus, inhibition of autophagy. 4. Inhibition of endosomal acidification. 5. Inhibition of MAP-Kinase, thus inhibiting molecular crosstalk in viruses, and inhibiting virus particle assembly and budding. @Corresponding author, Sahu M, Shankar SH, <i>et al</i>.