Journal of Primary Care Specialties

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 3  |  Issue : 2  |  Page : 33--39

Serum homocysteine in intracerebral hemorrhage: A savior or a destroyer?


Debabrata Chakraborty1, Sadanand Dey1, Sanjay Bhaumik1, Aditya Choudhary1, Kishalaya Karan1, Pradipta Bhattacharjee1, Priyanjita Sen1, Mohuya Mukherjee1, Gobinda Pramanick2, Nirmalya Ray2, Payel Biswas2, Jayanta Roy3, Satya Narayan Singh4, Binod Kumar Singhania4, Biswajit Sengupta4, Kajal Das4, Gopal Acharya4, Bhaskar Ukil4, Rahul Ghosh4 
1 Department of Neurology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India
2 Department of Radiology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India
3 Department of Neurology, Institute of Neurosciences, Kolkata, West Bengal, India
4 Department of Neurosurgery, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India

Correspondence Address:
Dr. Debabrata Chakraborty
64/4A/9, Beliaghata Main Road, Kolkata - 700 010, West Bengal
India

Objectives: Intracerebral hemorrhage (ICH) is more common in the Indian subcontinent compared to the Western world and associated with significant morbidity and mortality. Hence, all possible modifiable factors should be searched and steps taken so that a single opportunity is not missed in preventing such a catastrophe. The aim of the study is to find out whether homocysteine and Vitamin B12 are related to ICH. Materials and Methods: We included acute ICH patients of 18 years and above who came to our institute and got admitted in 5 months (September 2021–January 2022). Our team noted the demographics, National Institutes of Health Stroke Scale (at admission and discharge) and other clinical parameters. Volume and site of the intracerebral hematoma (from the initial computed tomography [CT] scan of the brain) were noted. The outcome and prognostic markers like Modified Rankin Scale (mRS) at discharge, MRS at 3 months (also MRS at admission) and ICH score were calculated. The blood parameters, including serum homocysteine and Vitamin B12 level, were noted post admission in hospital. Results: We found out of 44 ICH patients; ten patients had hyperhomocysteinemia (HHcy): 22.72%. We detected significant correlation between HHCy with ICH score (inverse relationship) and dyslipidemia (direct relationship). Conclusion: We found an inverse correlation between serum homocysteine level and ICH score, which shows a short-term (1 month) prognosis. This might hint that homocysteine might have a protective role to play in ICH. However, we probably need larger study population to find a correlation strong enough so that we can make a stronger conclusion.


How to cite this article:
Chakraborty D, Dey S, Bhaumik S, Choudhary A, Karan K, Bhattacharjee P, Sen P, Mukherjee M, Pramanick G, Ray N, Biswas P, Roy J, Singh SN, Singhania BK, Sengupta B, Das K, Acharya G, Ukil B, Ghosh R. Serum homocysteine in intracerebral hemorrhage: A savior or a destroyer?.J Prim Care Spec 2022;3:33-39


How to cite this URL:
Chakraborty D, Dey S, Bhaumik S, Choudhary A, Karan K, Bhattacharjee P, Sen P, Mukherjee M, Pramanick G, Ray N, Biswas P, Roy J, Singh SN, Singhania BK, Sengupta B, Das K, Acharya G, Ukil B, Ghosh R. Serum homocysteine in intracerebral hemorrhage: A savior or a destroyer?. J Prim Care Spec [serial online] 2022 [cited 2022 Aug 8 ];3:33-39
Available from: https://www.jpcsonline.org/article.asp?issn=2772-3615;year=2022;volume=3;issue=2;spage=33;epage=39;aulast=Chakraborty;type=0