Journal of Primary Care Specialties

REVIEW ARTICLE
Year
: 2021  |  Volume : 2  |  Issue : 2  |  Page : 33--37

Renin-angiotensin system in the pathogenesis of COVID-19 and possible drug targets


Sujay Halkur Shankar, Arvind Kumar, Diksha Patidar, Sai Krishna Kanukuntla, Naveet Wig 
 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Arvind Kumar
Room 3094-A, 3rd Floor, Teaching Block, All India Institute of Medical Sciences, New Delhi - 110 029
India

Coronavirus disease 2019 (COVID-19) is characterized by fever, cough, shortness of breath, myalgia, and headache. The disease also takes a more severe form with life-threatening manifestations of acute respiratory distress syndrome, acute cardiac injury, acute kidney injury, disseminated intravascular coagulopathy, and cytokine storm. It has been elucidated that like its predecessor, the SARS CoV, the SARS CoV-2 utilizes the angiotensin-converting enzyme 2 receptor to enter cells. This knowledge brought into speculation the effects of a dysregulated renin-angiotensin system (RAS) in the pathogenesis of COVID-19. It has been proposed that the effects of a dysregulated RAS would lead to an inflammatory cascade and contribute to the cytokine storm that is central to the disease. This paper looks at the RAS pathway and hypothesizes the possibility of a positive RAS feedback loop in the pathogenesis of COVID-19.


How to cite this article:
Shankar SH, Kumar A, Patidar D, Kanukuntla SK, Wig N. Renin-angiotensin system in the pathogenesis of COVID-19 and possible drug targets.J Prim Care Spec 2021;2:33-37


How to cite this URL:
Shankar SH, Kumar A, Patidar D, Kanukuntla SK, Wig N. Renin-angiotensin system in the pathogenesis of COVID-19 and possible drug targets. J Prim Care Spec [serial online] 2021 [cited 2021 Oct 27 ];2:33-37
Available from: http://www.jpcs.com/article.asp?issn=2772-3615;year=2021;volume=2;issue=2;spage=33;epage=37;aulast=Shankar;type=0