| ORIGINAL ARTICLE |
|
| Year : 2023 | Volume
: 4
| Issue : 1 | Page : 3-9 |
|
|
Blood counts and homocysteine in acute stroke: What is the relation?
Debabrata Chakraborty1, Pradipta Bhattacharjee1, Sadanand Dey1, Sanjay Bhaumik1, Aditya Choudhary1, Kishalaya Karan1, Priyanjita Sen1, Mohuya Mukherjee1, Gobinda Pramanick2, Nirmalya Ray2, Anupam Chakrapani3, Satya Narayan Singh4, Binod Kumar Singhania4, Biswajit Sengupta4, Kajal Das4, Aditya Mantry4, Bhaskar Ukil4, Rahul Ghosh4
1 Department of Neurology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India
2 Department of Radiology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India
3 Department of Haematology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India
4 Department of Neurosurgery, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India
Correspondence Address:
Dr. Debabrata Chakraborty
64/4A/9, Beliaghata Main Road, Kolkata - 700 010, West Bengal
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/jopcs.jopcs_21_22
|
|
|
Objectives: Stroke is the second-leading cause of death and the third-leading cause of death and disability combined in the world. We need to find easy, available, and reliable parameters on which we can depend to prevent stroke, predict outcome, and determine prognosis. This will help in stroke management in the future. Materials and Methods: We noted blood counts and serum homocysteine levels in acute stroke patients after the exclusion of confounding factors. Our team recorded the detailed demographic and blood parameters (blood counts and homocysteine) of acute stroke patients who got admitted to different departments of our hospital in 5 months. We later correlated or tried to find the association between these parameters and stroke severity (NIHSS), other clinical parameters such as dysarthria and stroke outcome (Modified Rankin Score (mRS) at discharge and at 3 months). The team also tried to find relationships, if any, with different stroke subtypes as per the Trial of ORG 10172 in Acute Stroke Treatment classification. Results: Out of 100 patients (34 females and 66 males), we had 28 patients with hyperhomocysteinemia (HHcy). The high neutrophil count and total leukocyte count correlated with stroke severity, dysarthria, and outcome at 3 months (poor mRS). While, it was the opposite in the case of lymphocyte count. Homocysteine level did not correlate with stroke severity or outcome but with dyslipidemia. HHcy was more prevalent among patients with large artery atherosclerotic disease. Conclusion: Findings of our study were agreeable to earlier studies on the relationship between blood counts and stroke prognosis. Although high homocysteine level was associated with stroke, its level was not found to be related to stroke severity or outcome. However, further study with a larger sample size is required to draw a confident conclusion.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
